Astrocyte development

Across TCGA cell cohorts, RNA activity of the Astrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTC1, CHML, and TTC38, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTC1 grouped by Astrocyte development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CTC1 →	+1.203	+1.387	.004	.002	3	4
LARGE_INTESTINE	CHML →	+0.819	+1.046	.008	<.001	3	4
LARGE_INTESTINE	TTC38 →	-1.188	-0.886	<.001	.007	3	4
URINARY_TRACT	TSACC →	+0.872	+1.971	.007	<.001	3	4
SKIN	NFKBIZ →	-1.129	-1.044	.001	.001	3	4
CNS	RFX3 →	+1.157	+0.940	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTC1 by Astrocyte development activity — STOMACH

Explore this box plot interactively →