Astrocyte development

Across TCGA cell cohorts, RNA activity of the Astrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SART1, SURF2, and IMPDH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Astrocyte development activity versus SART1 in LIVER (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SART1 →	-0.624	-1.483	<.001	<.001	3	4
CNS	SURF2 →	-0.838	-1.532	<.001	<.001	3	4
PANCREAS	IMPDH2 →	-0.776	-0.743	<.001	.009	3	4
SKIN	CHCHD4 →	-0.671	-0.542	.004	.008	3	4
SKIN	M6PR →	-0.646	-0.945	.004	.008	3	4
LUNG_NSCLC_LUAD	CUL4A →	-0.826	-0.960	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014002 vs SART1 — LIVER

Explore this scatter interactively →