Response to auditory stimulus

Across TCGA patient cohorts, RNA activity of the Response to auditory stimulus pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A3, MFSD6L, and PTN, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to auditory stimulus activity versus SLC1A3 in ESCA (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	SLC1A3 →	+0.977	+0.050	<.001	<.001	3	17
CESC	MFSD6L →	-0.942	-0.030	<.001	<.001	3	14
PCPG	PTN →	+1.719	+0.024	<.001	<.001	3	12
ESCA	ASRGL1 →	-1.164	-0.058	<.001	<.001	3	12
ESCA	SEC11C →	-0.607	-0.037	<.001	<.001	3	12
LUSC	RASL11A →	-0.870	-0.022	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010996 vs SLC1A3 — ESCA

Explore this scatter interactively →