Response to auditory stimulus

Across TCGA patient cohorts, RNA activity of the Response to auditory stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHKB_S704, AKR1B1, and ING4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to auditory stimulus activity versus PHKB_S704 in GBM (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PHKB_S704 →	+0.805	+0.098	.002	.006	3	5
OV	AKR1B1 →	-0.431	-0.049	.001	.007	3	4
GBM	ING4 →	-0.218	-0.051	.007	.001	3	4
CCRCC	POLR1D →	-0.102	-0.033	.005	.002	3	4
HNSC	GYS1 →	+0.340	+0.053	<.001	.002	3	4
HNSC	ABLIM2 →	+0.963	+0.046	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010996 vs PHKB_S704 — GBM

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