Response to auditory stimulus

Across TCGA patient cohorts, RNA activity of the Response to auditory stimulus pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANO5, ECSCR, and MEF2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to auditory stimulus activity versus ANO5 in HNSC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ANO5 →	+0.947	+0.535	<.001	.004	3	5
CCRCC	ECSCR →	+0.732	+0.619	.001	.002	3	5
HNSC	MEF2C →	+0.725	+0.566	<.001	<.001	3	5
BRCA	CAVIN2 →	+1.277	+0.465	<.001	.001	3	5
BRCA	VWF →	+0.824	+0.416	.001	.008	3	5
HNSC	RAMP3 →	+1.157	+0.795	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010996 vs ANO5 — HNSC

Explore this scatter interactively →