Ubiquitin recycling

Across TCGA patient cohorts, RNA activity of the Ubiquitin recycling pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXW7, OTUD3, and ZNF518A, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin recycling activity versus FBXW7 in UVM (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	FBXW7 →	+0.920	+0.059	<.001	<.001	3	27
UVM	OTUD3 →	+0.952	+0.049	<.001	<.001	3	27
UVM	ZNF518A →	+1.280	+0.063	<.001	<.001	3	27
ESCA	GTF3C2-AS1 →	+0.347	+0.065	<.001	<.001	3	27
DLBC	RN7SL481P →	+0.810	+0.043	.001	.004	3	27
UVM	ARID1A →	+1.037	+0.062	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010992 vs FBXW7 — UVM

Explore this scatter interactively →