Ubiquitin recycling

Across TCGA patient cohorts, RNA activity of the Ubiquitin recycling pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANLN_S485, PEX14_S44, and SAMHD1_T592, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin recycling activity versus ANLN_S485 in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANLN_S485 →	+1.399	+0.069	<.001	.002	3	6
LUAD	PEX14_S44 →	+0.572	+0.074	<.001	<.001	3	6
LUAD	SAMHD1_T592 →	+0.568	+0.048	.004	.005	3	5
PDAC	CHAF1B_S410 →	+0.701	+0.081	<.001	<.001	3	5
LUAD	DLGAP4_T915 →	+0.815	+0.069	<.001	<.001	3	5
LUAD	ECT2_T359 →	+1.051	+0.077	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010992 vs ANLN_S485 — UCEC

Explore this scatter interactively →