Ubiquitin recycling

Across TCGA cell cohorts, RNA activity of the Ubiquitin recycling pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP19, HNRNPA1, and RPL3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin recycling activity versus ARHGAP19 in BONE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ARHGAP19 →	+1.808	+1.664	<.001	<.001	3	7
STOMACH	HNRNPA1 →	+1.052	+1.645	.004	<.001	3	7
STOMACH	RPL3 →	+1.068	+1.538	.001	<.001	3	7
BLOOD_Leukemia	KHDRBS1 →	+0.488	+0.610	<.001	<.001	3	6
BLOOD_Leukemia	NONO →	+0.509	+0.545	<.001	.001	3	6
LIVER	PCBP2 →	+0.502	+1.090	.008	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010992 vs ARHGAP19 — BONE

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