Negative regulation of low-density lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Negative regulation of low-density lipoprotein particle clearance pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GTPBP3, ATP5PO, and BICD2_S331, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of low-density lipoprotein particle clearance activity versus GTPBP3 in LSCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GTPBP3 →	+0.277	+0.073	.001	.005	3	4
LSCC	ATP5PO →	+0.186	+0.091	<.001	<.001	3	3
LSCC	BICD2_S331 →	+1.426	+0.137	<.001	.002	3	3
LSCC	MARK2 →	+0.160	+0.081	.002	.003	3	3
LSCC	PLD1 →	+0.477	+0.097	.003	.003	3	3
GBM	RPL34_S12 →	+0.647	+0.087	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010989 vs GTPBP3 — LSCC

Explore this scatter interactively →