Negative regulation of low-density lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Negative regulation of low-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDLR, PCSK9, and IPCEF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of low-density lipoprotein particle clearance activity versus LDLR in LSCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LDLR →	+0.583	+0.130	<.001	.001	3	5
HNSC	PCSK9 →	+1.974	+0.217	<.001	<.001	3	4
LUAD	IPCEF1 →	-0.708	-0.153	.001	.002	3	4
LSCC	SLC2A1 →	+0.993	+0.142	<.001	.004	3	4
UCEC	FASN →	+0.886	+0.096	<.001	<.001	3	4
CCRCC	TRAV29DV5 →	-0.819	-0.145	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010989 vs LDLR — LSCC

Explore this scatter interactively →