Negative regulation of low-density lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Negative regulation of low-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST14, APP, and B3GAT3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ST14 grouped by Negative regulation of low-density lipoprotein particle clearance-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ST14 →	-4.533	-0.497	.004	.004	3	4
CNS	APP →	+0.850	+0.827	.003	.003	3	4
PANCREAS	B3GAT3 →	+0.837	+1.370	.003	.004	3	4
URINARY_TRACT	PRNP →	+1.508	+1.687	.003	<.001	3	4
BREAST	CAP2 →	+1.654	+0.618	<.001	.003	3	4
OVARY	LSM8 →	+1.027	+1.031	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ST14 by Negative regulation of low-density lipoprotein particle clearance activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →