Negative regulation of lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipoprotein particle clearance pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARP14, LGALS9, and SH3BP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipoprotein particle clearance activity versus PARP14 in COAD (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PARP14 →	+0.328	+0.070	<.001	<.001	3	5
CCRCC	LGALS9 →	+0.413	+0.058	<.001	.002	3	5
LUAD	SH3BP1 →	+0.238	+0.072	.001	.001	3	4
COAD	CCDC88B →	+0.427	+0.058	.009	.004	3	4
LSCC	PYCARD →	+0.269	+0.060	.008	.008	2	5
PDAC	LCP1 →	+0.179	+0.043	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010985 vs PARP14 — COAD

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