Negative regulation of lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANGPTL2, C3orf80, and LGALS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipoprotein particle clearance activity versus ANGPTL2 in LSCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANGPTL2 →	+0.638	+0.149	.002	.001	3	3
LSCC	C3orf80 →	+0.606	+0.212	<.001	<.001	3	3
LSCC	LGALS1 →	+0.709	+0.160	<.001	.001	3	3
CCRCC	RSPH14 →	-0.639	-0.156	<.001	<.001	3	3
LSCC	SPARC →	+0.666	+0.148	.002	.002	3	3
LSCC	POSTN →	+0.708	+0.141	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010985 vs ANGPTL2 — LSCC

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