Negative regulation of lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2B5, PLA2G15, and ATF6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF2B5 grouped by Negative regulation of lipoprotein particle clearance-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EIF2B5 →	-0.873	-1.412	.004	.002	3	4
STOMACH	PLA2G15 →	+1.239	+0.989	<.001	.009	3	4
SKIN	ATF6 →	+0.727	+0.735	<.001	.003	3	4
STOMACH	NFE2L1 →	+1.191	+1.392	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SLC25A23 →	+1.888	+1.578	.004	.005	3	4
BLOOD_Lymphoma	PRNP →	+0.825	+1.868	.006	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF2B5 by Negative regulation of lipoprotein particle clearance activity — OESOPHAGUS

Explore this box plot interactively →