Positive regulation of high-density lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Positive regulation of high-density lipoprotein particle clearance pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP1A1_S16, GSDME, and P4HB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of high-density lipoprotein particle clearance activity versus ATP1A1_S16 in OV (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ATP1A1_S16 →	-0.659	-0.104	.002	.002	3	4
CCRCC	GSDME →	+0.391	+0.054	.003	.009	3	4
COAD	P4HB →	+0.236	+0.080	.003	.003	3	4
CCRCC	RPS14 →	+0.123	+0.048	.002	.002	3	3
LSCC	TBC1D2 →	+0.289	+0.044	<.001	.001	3	3
LSCC	ZNF503_S102 →	-0.453	-0.053	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010983 vs ATP1A1_S16 — OV

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