Positive regulation of high-density lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Positive regulation of high-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNMB1, KAT6B, and R3HCC1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of high-density lipoprotein particle clearance activity versus KCNMB1 in UCEC (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCNMB1 →	+1.934	+0.104	<.001	.001	3	4
GBM	KAT6B →	-0.648	-0.199	<.001	<.001	3	4
LUAD	R3HCC1L →	-0.370	-0.143	.006	.001	3	3
GBM	SERPINE1 →	+1.669	+0.128	<.001	<.001	3	3
GBM	DCN →	+1.562	+0.156	<.001	<.001	3	3
GBM	CNN1 →	+1.180	+0.144	.002	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010983 vs KCNMB1 — UCEC

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