Positive regulation of high-density lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Positive regulation of high-density lipoprotein particle clearance pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC71, NFATC3, and ZYX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC71 grouped by Positive regulation of high-density lipoprotein particle clearance-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CCDC71 →	+0.265	+1.754	<.001	<.001	3	4
PANCREAS	NFATC3 →	-0.199	-1.514	.001	<.001	3	4
STOMACH	ZYX →	-0.191	-1.438	.003	<.001	3	4
LUNG_NSCLC_LUAD	ARF4 →	-0.249	-0.685	.001	.004	3	4
LUNG_NSCLC_LUAD	PPP1CB →	+0.308	+0.801	<.001	<.001	3	4
SKIN	RPL15 →	+0.368	+0.165	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC71 by Positive regulation of high-density lipoprotein particle clearance activity — PANCREAS

Explore this box plot interactively →