Regulation of high-density lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Regulation of high-density lipoprotein particle clearance pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM1_S207, AKAP1, and POLR3G_S157, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of high-density lipoprotein particle clearance activity versus SRRM1_S207 in HNSC (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SRRM1_S207 →	-0.174	-0.058	.005	.006	3	3
HNSC	AKAP1 →	-0.271	-0.080	.002	.001	3	3
HNSC	POLR3G_S157 →	-0.525	-0.081	.007	.003	3	3
LSCC	ZMYM4_S1030 →	-0.259	-0.042	.005	.001	3	3
BRCA	COPE →	+0.171	+0.105	.004	.001	3	3
COAD	MTX1 →	-0.219	-0.076	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010982 vs SRRM1_S207 — HNSC

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