Regulation of high-density lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Regulation of high-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARMN, STAB1, and FAM20A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of high-density lipoprotein particle clearance activity versus CARMN in OV (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CARMN →	+0.734	+0.094	.003	.003	3	4
HNSC	STAB1 →	+1.418	+0.115	<.001	.003	3	4
HNSC	FAM20A →	+1.439	+0.122	.006	.001	3	4
GBM	LBP →	+0.840	+0.152	.004	<.001	3	4
HNSC	LYVE1 →	+2.313	+0.115	<.001	.003	3	4
BRCA	FES →	+0.603	+0.112	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010982 vs CARMN — OV

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