Regulation of high-density lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Regulation of high-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS19, HNRNPA1, and NCK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS19 grouped by Regulation of high-density lipoprotein particle clearance-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RPS19 →	-0.866	-1.514	<.001	<.001	3	5
LUNG_SCLC	HNRNPA1 →	-0.561	-1.548	<.001	<.001	3	5
LUNG_NSCLC_LUAD	NCK2 →	+0.709	+0.967	.005	.002	3	4
BONE	UBE2R2 →	+0.496	+1.096	.005	.007	3	4
LIVER	AGPS →	+0.720	+1.933	.004	.003	3	4
LARGE_INTESTINE	RPL27A →	-0.870	-1.710	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS19 by Regulation of high-density lipoprotein particle clearance activity — PANCREAS

Explore this box plot interactively →