Negative regulation of neuron projection development

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuron projection development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF11, MTPAP, and GPR160, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF11 grouped by Negative regulation of neuron projection development-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KIF11 →	+0.685	+0.230	.008	.007	3	4
STOMACH	MTPAP →	+0.863	+0.248	.003	.005	3	3
UPPER_AERODIGESTIVE_TRACT	GPR160 →	+1.190	+0.218	.004	.003	3	3
LARGE_INTESTINE	DNASE1 →	-0.585	-0.466	.005	.009	3	3
URINARY_TRACT	PLK4 →	+0.694	+0.268	.001	<.001	3	3
URINARY_TRACT	CPPED1 →	-3.258	-0.268	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF11 by Negative regulation of neuron projection development activity — URINARY_TRACT

Explore this box plot interactively →