Transport along microtubule

Across TCGA patient cohorts, RNA activity of the Transport along microtubule pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARL6, WDR19, and IFT122, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transport along microtubule activity versus ARL6 in LSCC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARL6 →	+0.412	+0.042	<.001	<.001	3	7
BRCA	WDR19 →	+0.340	+0.021	<.001	<.001	3	7
UCEC	IFT122 →	+0.423	+0.044	<.001	.005	3	7
BRCA	DTX3 →	+0.343	+0.021	<.001	<.001	3	7
BRCA	PRKRA →	+0.223	+0.022	.001	<.001	3	7
BRCA	IFT22 →	+0.302	+0.020	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010970 vs ARL6 — LSCC

Explore this scatter interactively →