Transport along microtubule

Across TCGA cell cohorts, RNA activity of the Transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPCDC, PRSS16, and EGF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPCDC grouped by Transport along microtubule-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PPCDC →	-1.141	-0.187	.006	<.001	3	4
BONE	PRSS16 →	-1.944	-0.197	<.001	<.001	3	4
KIDNEY	EGF →	+1.026	+0.146	.005	.006	3	4
PANCREAS	ARMCX1 →	+1.486	+0.206	.005	<.001	3	4
PANCREAS	CCN1 →	+2.927	+0.228	<.001	<.001	3	4
PANCREAS	SHISA5 →	+0.617	+0.156	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPCDC by Transport along microtubule activity — OESOPHAGUS

Explore this box plot interactively →