Transport along microtubule

Across TCGA cell cohorts, RNA activity of the Transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSFM, RPL4, and DARS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transport along microtubule activity versus TSFM in CNS (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TSFM →	-0.375	-0.135	.001	.001	3	6
OESOPHAGUS	RPL4 →	-0.937	-0.254	<.001	<.001	3	6
OESOPHAGUS	DARS2 →	-0.710	-0.177	<.001	.002	3	5
OESOPHAGUS	RPS7 →	-0.974	-0.188	.001	<.001	3	5
STOMACH	POFUT2 →	+1.288	+0.177	.006	.001	3	5
SOFT_TISSUE	SCO1 →	-0.833	-0.191	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010970 vs TSFM — CNS

Explore this scatter interactively →