Negative regulation of vitamin D biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of vitamin D biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK10, TBC1D2B_T277, and DOK2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vitamin D biosynthetic process activity versus STK10 in OV (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STK10 →	+0.368	+0.063	<.001	.001	3	10
CCRCC	TBC1D2B_T277 →	+0.698	+0.067	.003	.001	3	8
BRCA	DOK2 →	+0.660	+0.062	<.001	<.001	3	8
HNSC	EHBP1L1 →	+0.327	+0.071	<.001	<.001	3	8
OV	PPP1R18 →	+0.369	+0.057	<.001	<.001	3	8
OV	PPP1R18_S368 →	+0.949	+0.068	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010957 vs STK10 — OV

Explore this scatter interactively →