Negative regulation of vitamin D biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of vitamin D biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LACC1, LINC02041, and TSPAN12, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vitamin D biosynthetic process activity versus LACC1 in LUAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LACC1 →	+0.261	+0.481	.009	.005	3	3
LSCC	LINC02041 →	-1.136	-0.294	<.001	.003	3	3
GBM	TSPAN12 →	-1.456	-0.728	<.001	<.001	3	3
UCEC	SLC40A1 →	+0.957	+0.552	.004	.004	3	3
OV	SPACA4 →	+0.661	+0.413	<.001	.005	3	2
OV	OR8A1 →	-0.071	-0.349	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010957 vs LACC1 — LUAD

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