Negative regulation of vitamin D biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of vitamin D biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP27B1, SNAI2, and SNAI1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP27B1 grouped by Negative regulation of vitamin D biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CYP27B1 →	-0.408	-1.680	<.001	<.001	3	9
BLOOD_Lymphoma	SNAI2 →	-0.310	-0.372	.005	.005	2	9
BREAST	SNAI1 →	-0.205	-0.962	<.001	<.001	3	6
CNS	GFI1 →	-0.209	-0.867	.002	.001	3	6
LUNG_SCLC	PRKCH →	-0.311	-1.333	.003	.002	3	4
BREAST	NFKB1 →	-0.187	-0.903	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP27B1 by Negative regulation of vitamin D biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →