Positive regulation of peptidase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of peptidase activity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTK2B, DPYD, and FNBP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peptidase activity activity versus PTK2B in GBM (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTK2B →	+0.624	+0.039	<.001	.001	3	9
LSCC	DPYD →	+0.511	+0.055	<.001	<.001	3	8
LSCC	FNBP1 →	+0.417	+0.045	<.001	<.001	3	8
GBM	HCLS1 →	+0.730	+0.050	<.001	<.001	3	8
LSCC	ANKRD44 →	+0.475	+0.057	<.001	<.001	3	8
LSCC	LAT_S224 →	+0.955	+0.043	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010952 vs PTK2B — GBM

Explore this scatter interactively →