Positive regulation of peptidase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of peptidase activity pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR8, AIM2, and PARP15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peptidase activity activity versus TLR8 in HNSC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TLR8 →	+0.750	+0.106	<.001	<.001	3	6
HNSC	AIM2 →	+1.007	+0.124	.007	.001	3	6
HNSC	PARP15 →	+0.705	+0.108	<.001	<.001	3	6
LSCC	IKZF1 →	+1.055	+0.216	.004	<.001	3	6
HNSC	ARHGAP30 →	+0.470	+0.124	.001	<.001	3	6
HNSC	CD74 →	+0.828	+0.102	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010952 vs TLR8 — HNSC

Explore this scatter interactively →