Positive regulation of peptidase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of peptidase activity pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC30, ZNF154, and SLC48A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC30 grouped by Positive regulation of peptidase activity-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CCDC30 →	+0.708	+1.419	.005	.002	2	5
CNS	ZNF154 →	+0.355	+0.580	.006	.006	3	4
SKIN	SLC48A1 →	+0.797	+0.884	.002	<.001	3	4
SKIN	ADGRL1 →	+0.716	+1.176	.001	<.001	3	4
URINARY_TRACT	DNAJB7 →	+0.123	+1.613	.001	<.001	3	4
KIDNEY	LRRC23 →	+0.981	+1.355	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC30 by Positive regulation of peptidase activity activity — KIDNEY

Explore this box plot interactively →