Negative regulation of transcription by competitive promoter binding
pathway activity — cross-omics
GO:0010944Cross-omicsSHRNA → SHRNACellPairwise association · TCGA cohorts
Across TCGA cell cohorts, RNA activity of the Negative regulation of transcription by competitive promoter binding pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.
The most reproducible pathway-associated genes across cancer lineages are HHEX, MAD2L2, and BHLHE41, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.
Each partner is linked to its corresponding Q-omics profile.
Pathway-associated genes by consensus
Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.