Negative regulation of macrophage cytokine production

Across TCGA cell cohorts, RNA activity of the Negative regulation of macrophage cytokine production pathway is significantly associated with the drug response of multiple features, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Temsirolimus, TAK-715, and ZSTK474, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Temsirolimus grouped by Negative regulation of macrophage cytokine production-low versus -high activity in KIDNEY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Temsirolimus →	-0.855	-1.812	.037	.013	2	1
KIDNEY	TAK-715 →	-0.839	-1.618	.018	.040	2	1
KIDNEY	ZSTK474 →	-0.320	-1.618	.013	.040	2	1
KIDNEY	CD532 →	+0.544	+1.812	.002	.013	2	1
KIDNEY	ARRY-520 →	+0.474	+1.655	.047	.007	2	1
KIDNEY	BAM7 →	+0.418	+1.655	.038	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Temsirolimus by Negative regulation of macrophage cytokine production activity — KIDNEY

Explore this box plot interactively →