Cellular component assembly involved in morphogenesis

Across TCGA patient cohorts, RNA activity of the Cellular component assembly involved in morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEPD, KCNQ5-AS1, and PRODH, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular component assembly involved in morphogenesis activity versus PEPD in OV (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PEPD →	+1.418	+0.274	.002	.006	3	2
OV	KCNQ5-AS1 →	-0.074	-0.346	.001	<.001	3	2
BRCA	PRODH →	+1.564	+0.425	.002	.001	3	2
BRCA	CAV1 →	+1.065	+0.359	.004	.004	3	2
BRCA	FNDC4 →	+1.063	+0.468	.001	<.001	3	2
BRCA	PXDN →	+1.364	+0.381	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010927 vs PEPD — OV

Explore this scatter interactively →