Cellular component assembly involved in morphogenesis

Across TCGA cell cohorts, RNA activity of the Cellular component assembly involved in morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP3, DOCK5, and STX12, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular component assembly involved in morphogenesis activity versus GBP3 in LUNG_NSCLC_LUSC (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GBP3 →	+4.094	+0.526	.002	<.001	3	7
BLOOD_Lymphoma	DOCK5 →	+1.909	+0.199	.003	.003	3	7
URINARY_TRACT	STX12 →	+0.633	+0.320	.001	.002	3	6
BLOOD_Lymphoma	NIBAN2 →	+2.436	+0.238	.002	<.001	3	6
URINARY_TRACT	SH3GLB1 →	+0.556	+0.365	.004	<.001	3	6
BLOOD_Lymphoma	SGMS2 →	+2.022	+0.225	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010927 vs GBP3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →