Positive regulation of mitochondrial membrane potential

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitochondrial membrane potential pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNPH1_S123, ACIN1_S655, and TCF20_S574, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial membrane potential activity versus DNPH1_S123 in BRCA (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DNPH1_S123 →	-0.815	-0.047	<.001	.001	3	5
PDAC	ACIN1_S655 →	-0.578	-0.059	.001	<.001	3	4
GBM	TCF20_S574 →	-0.378	-0.054	.002	<.001	3	4
PDAC	AKAP11_T1485 →	-0.442	-0.046	.009	.002	3	4
PDAC	FOXK1_S223 →	-0.379	-0.036	.008	.004	3	4
LSCC	KAZN_S346 →	+0.533	+0.043	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010918 vs DNPH1_S123 — BRCA

Explore this scatter interactively →