Positive regulation of mitochondrial membrane potential

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitochondrial membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-888P, MTND4P24, and NPM1P6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial membrane potential activity versus RNU6-888P in PDAC (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RNU6-888P →	-0.367	-0.124	.005	.006	3	4
UCEC	MTND4P24 →	-2.065	-0.117	.004	.004	3	4
UCEC	NPM1P6 →	-0.682	-0.122	.002	.003	3	4
BRCA	HCFC2 →	+0.349	+0.106	.002	.006	3	4
BRCA	CLOCK →	+0.375	+0.108	<.001	.005	3	4
BRCA	DNAJB14 →	+0.493	+0.139	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010918 vs RNU6-888P — PDAC

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