Positive regulation of mitochondrial membrane potential

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitochondrial membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUGT1, PTP4A3, and INKA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUGT1 grouped by Positive regulation of mitochondrial membrane potential-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SUGT1 →	-0.891	-0.186	.001	.002	3	4
KIDNEY	PTP4A3 →	+2.223	+0.169	<.001	<.001	3	4
OESOPHAGUS	INKA1 →	-1.113	-0.147	.005	.003	3	4
KIDNEY	GPAA1 →	+0.815	+0.199	.001	<.001	3	4
LUNG_NSCLC_LUSC	COL7A1 →	-3.491	-0.312	<.001	<.001	3	3
OVARY	ARSG →	+1.006	+0.213	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUGT1 by Positive regulation of mitochondrial membrane potential activity — OVARY

Explore this box plot interactively →