Regulation of isomerase activity

pathway activity — cross-omics
GO:0010911Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of isomerase activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DHX9_S87, SEC16A_S2271, and TOP2B_S1550, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCADHX9_S87 →+0.745+0.192<.001<.00135
HNSCSEC16A_S2271 →-0.526-0.159<.001.00133
UCECTOP2B_S1550 →+0.403+0.200.003<.00133
COADGPKOW_S42 →+0.385+0.258.002<.00133
HNSCLIMA1_S230 →-0.557-0.183<.001<.00133
PDACSNRPD3 →+0.333+0.293<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration