Positive regulation of glucose metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of glucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASAH1, IGFBP6, and SELENOP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glucose metabolic process activity versus ASAH1 in SKIN (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ASAH1 →	-1.910	-0.841	<.001	.001	3	4
KIDNEY	IGFBP6 →	+2.986	+0.401	.001	<.001	3	4
BREAST	SELENOP →	-2.020	-0.532	.005	.009	3	4
STOMACH	EIF2A →	-0.624	-1.089	.001	.002	3	4
STOMACH	RASSF3 →	-1.048	-0.907	.002	.005	3	4
OESOPHAGUS	DYNC2LI1 →	-0.792	-0.551	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010907 vs ASAH1 — SKIN

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