Regulation of glucose metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of glucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENPP1, IRS2, and SV2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucose metabolic process activity versus ENPP1 in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ENPP1 →	+0.848	+0.153	.001	.003	3	5
LUAD	IRS2 →	+0.972	+0.150	<.001	.002	3	4
BRCA	SV2A →	+0.479	+0.118	.002	.006	3	4
CCRCC	PRPF8 →	+0.349	+0.276	<.001	.007	3	4
HNSC	FSIP2 →	+0.817	+0.228	.002	.006	3	4
LSCC	SORBS1 →	+0.630	+0.160	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010906 vs ENPP1 — LSCC

Explore this scatter interactively →