Regulation of glucose metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of glucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS10, CEP55, and CMSS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPS10 grouped by Regulation of glucose metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MRPS10 →	-0.985	-0.250	<.001	.004	3	5
STOMACH	CEP55 →	-1.312	-0.227	<.001	.002	3	5
LIVER	CMSS1 →	-0.908	-0.286	<.001	<.001	3	5
PANCREAS	CTNNAL1 →	-1.267	-0.201	.001	.001	2	5
PANCREAS	AP2B1 →	-0.998	-0.208	.004	.007	3	4
LARGE_INTESTINE	FAAH2 →	+1.235	+0.225	.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPS10 by Regulation of glucose metabolic process activity — STOMACH

Explore this box plot interactively →