Regulation of glucose metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of glucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFB7, COX6B2, and CORO6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucose metabolic process activity versus NDUFB7 in KIDNEY (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NDUFB7 →	-0.877	-0.300	.004	.009	3	3
KIDNEY	COX6B2 →	+0.350	+0.376	<.001	.002	3	3
KIDNEY	CORO6 →	+2.353	+0.272	<.001	.007	3	3
KIDNEY	NOP10 →	-1.129	-0.296	.004	.007	3	3
LUNG_NSCLC_LUSC	GCC2 →	+0.665	+0.276	.003	.006	3	3
LUNG_NSCLC_LUSC	EED →	+0.725	+0.223	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010906 vs NDUFB7 — KIDNEY

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