Positive regulation of triglyceride catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of triglyceride catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFIP11, FSD1, and HIRIP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of triglyceride catabolic process activity versus TFIP11 in CCRCC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TFIP11 →	-0.201	-0.245	.003	.009	3	4
GBM	FSD1 →	-0.594	-0.448	<.001	.008	3	3
GBM	HIRIP3 →	-0.338	-0.532	<.001	.002	3	3
BRCA	RPL38P2 →	+0.764	+0.146	.001	<.001	3	3
CCRCC	NUTF2P6 →	-0.577	-0.189	<.001	.006	3	3
BRCA	TBC1D3P2 →	+0.024	+0.148	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010898 vs TFIP11 — CCRCC

Explore this scatter interactively →