Positive regulation of triglyceride catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of triglyceride catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AADAC, NF1, and APOA4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AADAC grouped by Positive regulation of triglyceride catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AADAC →	-0.510	-1.813	.004	<.001	3	9
SKIN	NF1 →	-0.178	-0.947	.009	.008	3	5
SOFT_TISSUE	APOA4 →	-0.308	-1.605	.004	.002	1	7
CNS	AQP4 →	-0.134	-1.162	.002	.001	3	5
SKIN	CD164 →	-0.102	-0.927	.008	.004	3	5
OVARY	PLXNA3 →	-0.177	-1.479	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AADAC by Positive regulation of triglyceride catabolic process activity — LUNG_SCLC

Explore this box plot interactively →