Positive regulation of triglyceride catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of triglyceride catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICAL2, ARHGAP32, and PBX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MICAL2 grouped by Positive regulation of triglyceride catabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MICAL2 →	-2.078	-1.029	.001	.001	3	5
PANCREAS	ARHGAP32 →	+2.416	+1.733	<.001	.001	3	5
LUNG_SCLC	PBX1 →	+2.671	+1.318	<.001	.002	3	5
CNS	ENPP4 →	+1.449	+1.103	.005	.004	3	4
BREAST	BPNT1 →	+0.768	+0.780	.001	.001	3	4
BREAST	MAP2K7 →	+0.802	+0.990	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MICAL2 by Positive regulation of triglyceride catabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →