Negative regulation of triglyceride catabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of triglyceride catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFNG, TYROBP, and CSF3R, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of triglyceride catabolic process activity versus MFNG in LSCC (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MFNG →	+0.651	+0.168	<.001	<.001	3	6
GBM	TYROBP →	+0.883	+0.150	<.001	<.001	3	6
LSCC	CSF3R →	+0.968	+0.116	<.001	.002	3	6
HNSC	DPEP2 →	+0.811	+0.287	<.001	<.001	3	6
HNSC	RASGRP4 →	+0.651	+0.309	<.001	<.001	3	6
HNSC	LST1 →	+0.956	+0.230	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010897 vs MFNG — LSCC

Explore this scatter interactively →