Negative regulation of triglyceride catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of triglyceride catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB18, ACAD8, and WDR5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB18 grouped by Negative regulation of triglyceride catabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RAB18 →	-0.195	-0.202	.004	.004	3	4
LARGE_INTESTINE	ACAD8 →	-0.117	-0.154	.009	.008	3	4
OVARY	WDR5 →	+0.729	+0.320	.002	<.001	3	4
BREAST	GTF3C1 →	+0.113	+0.102	.008	.003	3	3
BONE	ARHGAP18 →	-0.255	-0.267	.004	.002	3	3
BONE	RAD17 →	-0.284	-0.290	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB18 by Negative regulation of triglyceride catabolic process activity — SOFT_TISSUE

Explore this box plot interactively →