Negative regulation of triglyceride catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of triglyceride catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP11, TRAM2, and GNG11, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of triglyceride catabolic process activity versus PARP11 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PARP11 →	+1.067	+0.622	.004	.006	3	3
UPPER_AERODIGESTIVE_TRACT	TRAM2 →	+1.044	+0.622	.004	.006	3	3
OVARY	GNG11 →	+3.816	+0.408	.003	.006	3	2
LUNG_SCLC	C20orf96 →	+1.035	+0.387	.005	<.001	3	2
OESOPHAGUS	LIN37 →	+1.121	+0.281	.003	.005	3	2
OESOPHAGUS	SUGP2 →	+0.657	+0.339	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010897 vs PARP11 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →