Regulation of triglyceride catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of triglyceride catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BLNK, ANKRD44, and THEMIS2_T593, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of triglyceride catabolic process activity versus BLNK in HNSC (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BLNK →	+0.438	+0.089	<.001	.001	3	7
UCEC	ANKRD44 →	+0.362	+0.058	<.001	.006	3	7
GBM	THEMIS2_T593 →	+0.734	+0.073	<.001	<.001	3	6
GBM	ARHGAP15_S43 →	+0.551	+0.060	<.001	<.001	3	6
HNSC	ARHGEF6 →	+0.391	+0.097	<.001	<.001	3	6
GBM	AATF →	-0.222	-0.057	.007	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010896 vs BLNK — HNSC

Explore this scatter interactively →