Regulation of triglyceride catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of triglyceride catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01147, GPA33, and MYO1F, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of triglyceride catabolic process activity versus LINC01147 in GBM (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LINC01147 →	+0.843	+0.273	<.001	.005	3	4
UCEC	GPA33 →	+0.570	+0.375	.007	.005	3	4
GBM	MYO1F →	+0.885	+0.315	<.001	.001	3	4
HNSC	JAML →	+0.800	+0.225	.003	.002	2	5
GBM	RIPK3 →	+0.810	+0.334	<.001	<.001	3	4
GBM	CSF3R →	+1.020	+0.304	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010896 vs LINC01147 — GBM

Explore this scatter interactively →